Syk Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Syk Kinase
  Conformer 1
(PDB) 		1a81 (A)
  Conformer 2
(PDB) 		1a81 (K)
  Window Length 15
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 21 0.55   114 - 168
2 98 0.3   16 - 113
3 87 0.36   169 - 255

Sequence


           ____________________________________________________________________________________________________111_________________ 
 1a81(A) : SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLI 
         :                                                                                                                          
 1a81(K) : SANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKT----------- 
           ____________________________________________________________________________________________________111_________________ 

           _____________________________________168________________________________________________________________________________ 
 1a81(A) : REYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKA 
         :                                                                                                                          
 1a81(K) : -----------------------pQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKA 
           _____________________________________168________________________________________________________________________________ 

           ______________                                                                                                           
 1a81(A) : DGLLRVLTVPCQKI                                                                                                           
         :                                                                                                                          
 1a81(K) : DGLLRVLTVPCQKI                                                                                                           
           ______________                                                                                                           

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		6.8
Translation
(A) 		0.2
Closure
(%) 		66.2
Bending Residues
( green ) 		  111 - 114
Bending Region Analysis
Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( yellow ) 		3
Rotation Angle
(deg) 		5.9
Translation
(A) 		-0.1
Closure
(%) 		45.5
Bending Residues
( green ) 		  168 - 169
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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