Thymidylate Synthase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Thymidylate Synthase
  Conformer 1
(PDB) 		3ihi (A)
  Conformer 2
(PDB) 		3ihh (A)
  Window Length 9
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 195 0.44   25 - 81   98 - 102   153 - 178   188 - 282   285 - 296
2 77 0.28   82 - 97   103 - 152   179 - 187   283 - 284

Sequence


           ___________________________________________________________81_____________96___102______________________________________ 
 3ihi(A) : RHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEY 
         :                                                                                                                          
 3ihh(A) : RHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEY 
           ___________________________________________________________81_____________96___102______________________________________ 

           _________152_______________________178_____186__________________________________________________________________________ 
 3ihi(A) : KDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLK 
         :                                                                                                                          
 3ihh(A) : KDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLK 
           _________152_______________________178_____186__________________________________________________________________________ 

           ___________________282_________________________                                                                          
 3ihi(A) : IQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPT*******                                                                          
         :                                                                                                                          
 3ihh(A) : IQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV                                                                          
           ___________________282_________________________                                                                          

Morph
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Status: Initialising

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		3.3
Translation
(A) 		0.1
Closure
(%) 		92.3
Bending Residues
( green ) 		  81 - 82
  96 - 98
  102 - 107
  152 - 153
  178 - 179
  186 - 188
  282 - 285
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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