Carboxyl-Terminal Src Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Carboxyl-Terminal Src Kinase
  Conformer 1
(PDB)
1k9a (B)
  Conformer 2
(PDB)
1k9a (F)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 134 0.86   8 - 71   180 - 229   232 - 236   239 - 241   249 - 255   262 - 266
2 111 0.96   74 - 179   230 - 231   256 - 258
3 182 0.67   237 - 238   242 - 248   267 - 448

Sequence


           __________________________________________________________________71____________________________________________________ 
 1k9a(B) : IQASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCE 
         :                                                                                                                          
 1k9a(F) : **ASWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCE 
           __________________________________________________________________71____________________________________________________ 

           _____________________________________________________179_______________________________________________229____236__241__ 
 1k9a(B) : GKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL 
         :                                                                                                                          
 1k9a(F) : GKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQL 
           _____________________________________________________179_______________________________________________229____236__241__ 

           __248____255________266_________________________________________________________________________________________________ 
 1k9a(B) : RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEAgKLPVKWTAPEALREKKFSTKSDV 
         :                                                                                                                          
 1k9a(F) : RHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEA---pVKWTAPEALREKKFSTKSDV 
           __248____255________266_________________________________________________________________________________________________ 

           _________________________________________________________________________________                                        
 1k9a(B) : WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL                                        
         :                                                                                                                          
 1k9a(F) : WSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYDVMKNCWHLDAATRPTFLQLREQLEHIRTHELHL                                        
           _________________________________________________________________________________                                        

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
13.4
Translation
(A)
0.0
Closure
(%)
21.3
Bending Residues
( green )
  71 - 76
  179 - 180
  229 - 232
  255 - 263
Bending Region Analysis
Property Value
Fixed Domain
( blue )
1
Moving Domain
( yellow )
3
Rotation Angle
(deg)
15.1
Translation
(A)
0.1
Closure
(%)
19.0
Bending Residues
( green )
  236 - 239
  241 - 242
  248 - 249
  266 - 267
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Shear

PyMOL Script

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