DNA Topoisomerase I

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name DNA Topoisomerase I
  Conformer 1
(PDB)
1cyy (B)
  Conformer 2
(PDB)
1cy9 (A)
  Window Length 11
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)
Residues
1 96 0.98   219 - 222   224 - 236   256 - 278   405 - 468
2 20 0.46   223 - 223   237 - 255
3 119 0.56   279 - 404

Sequence


           ______222___________236________________255____________________278_______________________________________________________ 
 1cyy(B) : FVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVN 
         :                                                                                                                          
 1cy9(A) : FVPEEFWEVDASTTTPSGEALALQVTHQNDKPFRPVNKEQTQAAVSLLEKARYSVLEREDKPTTSKPGAPFITSTLQQAASTRLGFGVKKTMMMAQRLYEAGYITYMRTDSTNLSQDAVN 
           ______222___________236________________255____________________278_______________________________________________________ 

           ______________________________________________________________403_______________________________________________________ 
 1cyy(B) : MVRGYISDNFGKKYLPESPNQYASeAHEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVMPALdRILPAVNKGDALTLVE 
         :                                                                                                                          
 1cy9(A) : MVRGYISDNFGKKYLPESPNQYAS--hEAIRPSDVNVMAESLKDMEADAQKLYQLIWRQFVACQMTPAKYDSTTLTVGAGDFRLKARGRILRFDGWTKVM---dRILPAVNKGDALTLVE 
           ______________________________________________________________403_______________________________________________________ 

           ___________                                                                                                              
 1cyy(B) : LTPAQHFTKPP                                                                                                              
         :                                                                                                                          
 1cy9(A) : LTPAQHFTKP*                                                                                                              
           ___________                                                                                                              

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue )
1
Moving Domain
( red )
2
Rotation Angle
(deg)
9.1
Translation
(A)
0.0
Closure
(%)
53.5
Bending Residues
( green )
  222 - 224
  236 - 237
  255 - 259
Bending Region Analysis
Property Value
Fixed Domain
( blue )
1
Moving Domain
( yellow )
3
Rotation Angle
(deg)
8.4
Translation
(A)
0.9
Closure
(%)
90.3
Bending Residues
( green )
  278 - 281
  403 - 405
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification:

No Contacts

PyMOL Script

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