Insulin Receptor Tyrosine Kinase Domain

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Insulin Receptor Tyrosine Kinase Domain
  Conformer 1
(PDB) 		1irk (A)
  Conformer 2
(PDB) 		1p14 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 208 1.24   1012 - 1012   1052 - 1071   1076 - 1281
2 72 0.98   983 - 1011   1013 - 1051   1072 - 1075

Sequence


           ______________________________1011____________________________________1051________________1071__________________________ 
 1irk(A) : ***SSVFVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAEN 
         :                                                                                                                          
 1p14(A) : VFPSSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAEN 
           ______________________________1011____________________________________1051________________1071__________________________ 

           ________________________________________________________________________________________________________________________ 
 1irk(A) : NPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQ 
         :                                                                                                                          
 1p14(A) : NPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRNLAARNCMVAHDFTVKIGDFG-------------------pVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQ 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________________________                                                       
 1irk(A) : VLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK                                                       
         :                                                                                                                          
 1p14(A) : VLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPNMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK                                                       
           __________________________________________________________________                                                       

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		10.5
Translation
(A) 		0.1
Closure
(%) 		50.7
Bending Residues
( green ) 		  1011 - 1013
  1051 - 1052
  1071 - 1072
  1075 - 1076
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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