Isocitrate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Isocitrate Dehydrogenase
  Conformer 1
(PDB) 		1lwd (B)
  Conformer 2
(PDB) 		3mas (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 240 1.13   6 - 120   286 - 411
2 146 0.95   121 - 271

Sequence


           ____________________________________________________________________________________________________________________119_ 
 1lwd(B) : ADQRIKVAKPVVEMDGDEMTRIIWQFIKEKLILPHVDVQLKYFDLGLPNRDQTNDQVTIDSALATQKYSVAVKCATITPDEARVEEFKLKKMWKSPNGTIRNILGGTVFREPIICKNIPR 
         :                                                                                                                          
 3mas(A) : ***KKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPR 
           ____________________________________________________________________________________________________________________118_ 

           ________________________________________________________________________________________________________________________ 
 1lwd(B) : LVPGWTKPITIGRHAHGDQYKATDFVVDRAGTFKIVFTPKDGSSAKQWEVYNFP-AGGVGMGMYNTDESISGFAHSCFQYAIQKKWPLYMSTKNTILKAYDGRFKDIFQEIFEKHYKTDF 
         :                                                                                                                          
 3mas(A) : LVSGWVKPIIIGHHA-----rATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQF 
           ________________________________________________________________________________________________________________________ 

           _____________________________271________________________________________________________________________________________ 
 1lwd(B) : DKYKIWYEHRLIDDMVAQVLKSSGGFVWACKNYDGDVQSDILAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYREHQKGRPTSTNPIASIFAWTRGLEHRGKLDGNQDLIRFAQTL 
         :                                                                                                                          
 3mas(A) : EAQKIWYEHRLIDDMVAQAMKSEGGFIWACKN--------------gSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANAL 
           _____________________________271________________________________________________________________________________________ 

           ________________________________________________________                                                                 
 1lwd(B) : EKVCVETVESGAMTKDLAGCIHGLSNVKLNEHFLNTSDFLDTIKSNLDRALGRQ**                                                                 
         :                                                                                                                          
 3mas(A) : EEVSIETIEAGFMTKDLAACIKGLPNVQRSD-YLNTFEFMDKLGENLKIKLAQAKL                                                                 
           ________________________________________________________                                                                 

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		23.7
Translation
(A) 		0.2
Closure
(%) 		61.4
Bending Residues
( green ) 		  119 - 123
  271 - 286
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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