Map Kinase P38

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Map Kinase P38
  Conformer 1
(PDB) 		1p38 (A)
  Conformer 2
(PDB) 		1cm8 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 209 2.91   79 - 85   109 - 172   179 - 324
2 113 3.76   8 - 78   86 - 108   173 - 178   328 - 348

Sequence


           _________________________________________________________________________78_____85____________________108_______________ 
 1p38(A) : ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLT 
         :                                                                                                                          
 1cm8(A) : *RSGFYRQEVTKTAWEVRAVYRDLQPV------aVCSAVDGRTGAKVAIKKLYRPFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLG 
           _________________________________________________________________________81_____88____________________111_______________ 

           ___________________________________________169__________________________________________________________________________ 
 1p38(A) : DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPG 
         :                                                                                                                          
 1cm8(A) : EDRIQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLARQADSEMg--vVTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMITGKTLFKGSDHLDQLKEIMKVTGTPP 
           ___________________________________________172__________________________________________________________________________ 

           ______________________________________________________________________________324______________________________          
 1p38(A) : AELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLD          
         :                                                                                                                          
 1cm8(A) : AEFVQRLQSDEAKNYMKGLPELEKKDFASILTNASPLAVNLLEKMLVLDAEQRVTAGEALAHPYFESLHq------VQKYD---DSrTL--DEWKRVTYKEVLSFKP****          
           ______________________________________________________________________________327______________________________          

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		31.9
Translation
(A) 		-0.8
Closure
(%) 		99.6
Bending Residues
( green ) 		  78 - 79
  85 - 86
  108 - 109
  169 - 186
  324 - 336
Bending Region Analysis

Dynamic Contact Graph

The dynamic contact graph is still being generated. Progress: Initialising

PyMOL Script

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