Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Metabotropic Glutamate Receptor Subtype 1
  Conformer 1
(PDB) 		1ewk (A)
  Conformer 2
(PDB) 		3ks9 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 270 0.48   38 - 209   344 - 474   476 - 476
2 167 0.87   210 - 343   475 - 475   477 - 510

Sequence


           ________________________________________________________________________________________________________________________ 
 1ewk(A) : *RSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIR---kPIAGVIGPGSSSVAIQVQNLLQLFDI 
         :                                                                                                                          
 3ks9(A) : QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLkPIAGVIGPGSSSVAIQVQNLLQLFDI 
           ________________________________________________________________________________________________________________________ 

           _________________________208____________________________________________________________________________________________ 
 1ewk(A) : PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL 
         :                                                                                                                          
 3ks9(A) : PQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLSIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLL 
           _________________________208____________________________________________________________________________________________ 

           _______________________________________342______________________________________________________________________________ 
 1ewk(A) : SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINAIYAM 
         :                                                                                                                          
 3ks9(A) : SAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPG-----pNFKRICTGNESLEENYVQDSKMGFVINAIYAM 
           _______________________________________342______________________________________________________________________________ 

           __________________________________________________473_______________________________________                             
 1ewk(A) : AHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKI                             
         :                                                                                                                          
 3ks9(A) : AHGLQNMHHALCPGHVGLCDAMKPIDGSKLLDFLIKSSFIGVSGEEVWFDEKGDAPGRYDIMNLQYTE--rYDYVHVGTWHEGVLNIDDYKI                             
           __________________________________________________473_______________________________________                             

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		31.6
Translation
(A) 		0.1
Closure
(%) 		99.8
Bending Residues
( green ) 		  208 - 210
  342 - 346
  473 - 479
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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