DynDom - Protein Domain Motions

Myosin-Vc

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Myosin-Vc
Conformer 1 (PDB)	4zg4 (B)
Conformer 2 (PDB)	1oe9 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	239	2.07	7 - 180 191 - 196 223 - 233 425 - 433 488 - 489 640 - 640 642 - 684
2	374	2.83	181 - 190 197 - 222 234 - 424 434 - 467 487 - 487 490 - 639 641 - 641
3	64	2.38	468 - 486 686 - 750

Sequence

`________________________________________________________________________________________________________________________` `4zg4(B) : MAVAELYTQYNRVWIPDPEEVWKSAEIAKDYRVG-kVLRLLLEDGELDYSVNPESLPPLRNPDILVGENDLTALSYLHEPAVLHNLRIRFAESKLIYTYSGIILVAMNPYKQLPIYGDAI` `:` `1oe9(A) : **ELYTKYARVWIPDPEEVWKSAELLKDYKPGDKVLQLRL---dLEYCL--kELPPLRNPDILVGENDLTALSYLHEPAVLHNLKVRFIDSKLIYTYCGIVLVAINPYEQLPIYGEDI` `________________________________________________________________________________________________________________________` `________________________________________________________180___________196_______________________222________233__________` `4zg4(B) : IHAYSGQNMGDMDPHIFAVAEEAYKQMARNNRNQSIIVSGESGAGKTVSARYAMRYFATVSKSGShVEDKVLASNPITEAVGNAKTTRNDNSSRFGKYTEISFDEQNQIIGANMSTYLLE` `:` `1oe9(A) : INAYSGQNMGDMDPHIFAVAEEAYKQMARDERNQSIIVSGESGAGKTVSAKYAMRYFATVS----nVEEKVLASNPIMESIGNAKTTRNDNSSRFGKYIEIGFDKRYRIIGANMRTYLLE` `________________________________________________________182___________198_______________________224________235__________` `________________________________________________________________________________________________________________________` `4zg4(B) : KSRVVFQSENERNYHIFYQLCASAQQSEFKHLKLGSAEEFNYTRMGGNTVIEGVNDRAEMVETQKTFTLLGFKEDFQMDVFKILAAILHLGNVQITAVGNERSSVSEDDSHLKVFCELLG` `:` `1oe9(A) : KSRVVFQAEEERNYHIFYQLCASAALPEFKTLRLGNANYFHYTKQGGSPVIDGIDDAKEMVNTRQACTLLGISDSYQMGIFRILAGILHLGNVEFASRDSDSCAIPPKHDPLTIFCDLMG` `________________________________________________________________________________________________________________________` `__________________________________________________________424______433_______________________________467__________480___` `4zg4(B) : LESGRVAQWLCNRKIVTSSETVVKPMTRPQAVNARDALAKKIYAHLFDFIVERINQALQFSGKQHTFIGVLDIYGFETFDVNSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEDIPWT` `:` `1oe9(A) : VDYEEMAHWLCHRKLAt----YIKPISKLHAINARDALAKHIYANLFNWIVDHVNKALHSTVKQHSFIGVLDIYGFETFEINSFEQFCINYANEKLQQQFNMHVFKLEQEEYMKEQIP--` `__________________________________________________________426______435_______________________________469__________482___` `_487____________________________________________________________________________________________________________________` `4zg4(B) :` `LIDFYDNQPVIDLIEAKMGILELLDEECLLPHGTDENWLQKLYNNFVNRNPLFEKPRMSNTSFVIQHFADKVEYKCEGFLEKNRDTVYDMLVEILRASK-FHLCANFFQENrTTVGSKFR` `:` `1oe9(A) :` `--dFYDNQPCINLIEAKMGVLDLLDEECKMPKGSDDTWAQKLYNTHLNKCALFEKPRLSNKAFIIKHFADKVEYQCEGFLEKNKDTVYEEQIKVLKSSKKFKLLPELFh--KKTVGHQFR` `_489____________________________________________________________________________________________________________________` `_______639_________________________________675__________________________________________________________________________` `4zg4(B) : SSLYLLMETLNATTPHYVRCIKPNDEKLPFEFDSKRIVQQLRACGVLETIRISAQSYPSR--yIEFYSRYk------------KEVCKVVLHRLIQDSNQYQFGKTKIFFR-gQVAYLEK` `:` `1oe9(A) : NSLHLLMETLNATTPHYVRCIKPNDFKFPFTFDEKRAVQQLRACGVLETIRISAAGFPSRWTYQEFFSRYRVLMKQKDVLSDRKQTCKNVLEKLILDKDKYQFGKTKIFFRAGQVAYLEK` `_______651_________________________________687__________________________________________________________________________` `_________________________________` `4zg4(B) : LR*****************************` `:` `1oe9(A) : IRADKLRAACIRIQKTIRGWLMRKKYMRMRRGD` `_________________________________`

Morph

Morph animation in progress.
Status: Initialising

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Fixed Domain	Moving Domain	Rotation Angle	Translation (A)	Closure	Bending Residues
1	2	22.7	1.5	69.7	180 - 193 196 - 197 222 - 223 233 - 234 424 - 425 433 - 434 487 - 490 639 - 642	Bending Region Analysis
1	3	89.3	3.3	47.4	480 - 488 675 - 686	Bending Region Analysis
2	3	81.0	0.1	14.5	467 - 468 480 - 487	Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification:

No Contacts

Conformer 1 Contact:
Residue 2 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 2

Movement classification:

No Contacts

PyMOL Script

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