DynDom - Protein Domain Motions

Protein (Lar)

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Protein (Lar)
Conformer 1 (PDB)	1lar (A)
Conformer 2 (PDB)	2fh7 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	280	0.77	1309 - 1494 1497 - 1585 1587 - 1587 1589 - 1592
2	277	0.9	1495 - 1496 1586 - 1586 1588 - 1588 1593 - 1873

Sequence

`________________________________________________________________________________________________________________________` `1lar(A) : ******MITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTAT` `:` `2fh7(A) : MLSHPPIPIADMAEHTERLKANDSLKLSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVILQPIEGIMGSDYINANYVDGYRRQNAYIATQGPLPETFGDFWRMVWEQRSAT` `________________________________________________________________________________________________________________________` `_______________________________________________________________________1494_____________________________________________` `1lar(A) : VVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAML` `:` `2fh7(A) : IVMMTRLEEKSRIKCDQYWPNRGTETYGFIQVTLLDTIELATFCVRTFSLHKNGSSEKREVRQFQFTAWPDHGVPEYPTPFLAFLRRVKTCNPPDAGPIVVHCSAGVGRTGCFIVIDAML` `_______________________________________________________________________1561_____________________________________________` `_________________________________________1584____1592___________________________________________________________________` `1lar(A) : ERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSsRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGV` `:` `2fh7(A) : ERIKPEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARSLYAYIQKLAQVEPGEHVTGMELEFKRLA----fISANLPCNKFKNRLVNIMPYESTRVCLQPIRGV` `_________________________________________1651____1659___________________________________________________________________` `________________________________________________________________________________________________________________________` `1lar(A) : EGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVP` `:` `2fh7(A) : EGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRMLWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVP` `________________________________________________________________________________________________________________________` `_____________________________________________________________________________________________` `1lar(A) : KTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSF` `:` `2fh7(A) : KSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALEYLGS` `_____________________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	11.1
Translation (A)	1.0
Closure (%)	80.7
Bending Residues ( green )	1494 - 1497 1584 - 1589 1592 - 1593
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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