Sr Protein Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Sr Protein Kinase
  Conformer 1
(PDB) 		1q8y (A)
  Conformer 2
(PDB) 		1q8y (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 57 0.24   148 - 190   230 - 246
2 20 0.29   191 - 210
3 263 0.39   211 - 228   248 - 735

Sequence


           ___________________________________________189__________________210_______________228______________245__________________ 
 1q8y(A) : YHPAFKGEPYKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHR 
         :                                                                                                                          
 1q8y(B) : **PAFKGEPYKDARYILVRKLG---fSTVWLAKDMVNNTHVAMKIVRGDKVYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVVMVFEVLGENLLALIKKYEHR 
           ___________________________________________189__________________210_______________228______________245__________________ 

           ________________________________________________________________________________________________________________________ 
 1q8y(A) : GIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLF---------kD 
         :                                                                                                                          
 1q8y(B) : GIPLIYVKQISKQLLLGLDYMHRRCGIIHTDIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTNSIQTREYRSPEVLLGAPWGCGADIWSTACLIFELITGDFLFEPDEGHSYTKD 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1q8y(A) : DDHIAQIIELLGELPSYLLRNGKYTRTFFNS--lLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPGWFEE 
         :                                                                                                                          
 1q8y(B) : DDHIAQIIELLGELPSYLLRNGKYTRTFFNSRGLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSPMLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPGWFEE 
           ________________________________________________________________________________________________________________________ 

           __                                                                                                                       
 1q8y(A) : VR                                                                                                                       
         :                                                                                                                          
 1q8y(B) : VR                                                                                                                       
           __                                                                                                                       

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Domain Pairs

Fixed Domain Moving Domain Rotation Angle Translation   (A) Closure Bending Residues  
1 2 5.6 0.0 39.9   189 - 192 Bending Region Analysis
1 3 11.3 -0.7 53.7   228 - 230   245 - 260 Bending Region Analysis
3 2 8.8 0.0 95.6   210 - 211 Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 3 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 3

Movement classification: Hinge

PyMOL Script

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