DynDom - Protein Domain Motions

Vitamin D Hydroxylase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Vitamin D Hydroxylase
Conformer 1 (PDB)	3a51 (B)
Conformer 2 (PDB)	3a4h (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	369	1.96	6 - 165 190 - 236 240 - 401
2	27	1.97	166 - 189 237 - 239

Sequence

`________________________________________________________________________________________________________________________` `3a51(B) : ALTTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQRADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEI` `:` `3a4h(A) : **TTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHTLPEDQRADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEI` `________________________________________________________________________________________________________________________` `_____________________________________161_________________________189________________________________________232____239__` `3a51(B) : ADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGLPAEDRDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAGHETT` `:` `3a4h(A) : ADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGVPAEDRDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDEDGDRLSQEELVAMAMLLLIAGHETT` `_____________________________________161_________________________189________________________________________232____239__` `________________________________________________________________________________________________________________________` `3a51(B) : VNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVFFGHGIHFCLGAQLARLEGRVAI` `:` `3a4h(A) : VNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVFFGHGIHFCLGAQLARLEGRVAI` `________________________________________________________________________________________________________________________` `__________________________________________` `3a51(B) : GRLFADRPELALAVGLDELVYRRSTLVRGLSRMPVTMGPRSA` `:` `3a4h(A) : GRLFADRPELALAVGLDELVYRESTLVRGLSRMPVTMGPRSA` `__________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	22.4
Translation (A)	-1.3
Closure (%)	19.0
Bending Residues ( green )	161 - 166 189 - 190 232 - 237 239 - 240
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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