Thymidylate Synthase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Thymidylate Synthase
  Conformer 1
(PDB) 		1i00 (B)
  Conformer 2
(PDB) 		1ju6 (D)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 170 0.64   62 - 70   84 - 84   86 - 181   183 - 207   231 - 249   278 - 297
2 102 0.7   32 - 61   71 - 83   85 - 85   182 - 182   208 - 230   250 - 277   298 - 303

Sequence


           ________________________________61_______70___________83________________________________________________________________ 
 1i00(B) : *SELQYLGQIQHILRCGVRKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYR 
         :                                                                                                                          
 1ju6(D) : HGELQYLGQIQHILRCGVEKDDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVKIWDANGSRDFLDSLGFSTREEGDLGPVYGFQWRHFGAEYR 
           ________________________________61_______70___________83________________________________________________________________ 

           _______________________________181_______________________207____________________230________________249__________________ 
 1i00(B) : DMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKI 
         :                                                                                                                          
 1ju6(D) : DMESDYSGQGVDQLQRVIDTIKTNPDDRRIIMCAWNPRDLPLMALPPCHALCQFYVVNSELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLKPGDFIHTLGDAHIYLNHIEPLKI 
           _______________________________181_______________________207____________________230________________249__________________ 

           _______277_________________297________________                                                                           
 1i00(B) : QLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPT*******                                                                           
         :                                                                                                                          
 1ju6(D) : QLQREPRPFPKLRILRKVEKIDDFKAEDFQIEGYNPHPTIKMEMAV                                                                           
           _______277_________________297________________                                                                           

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		5.9
Translation
(A) 		0.3
Closure
(%) 		88.2
Bending Residues
( green ) 		  61 - 62
  70 - 71
  83 - 86
  181 - 183
  207 - 208
  230 - 231
  249 - 250
  277 - 278
  297 - 298
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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