DynDom - Protein Domain Motions

Histidyl-Trna Synthetase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Histidyl-Trna Synthetase
Conformer 1 (PDB)	3hri (A)
Conformer 2 (PDB)	3lc0 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	370	1.9	49 - 215 218 - 248 267 - 470
2	20	0.6	216 - 217 249 - 266

Sequence

`________________________________________________________________________________________________________________________` `3hri(A) : MVETEPVQGCRDFPPETMRLRKYLFDVFHSTARKFGFEEYDSPVLESEELYIRKAGEEITEQMFNFIT---hRVALRPEMTPSLARQLLAKGRSLLLPAKWYSIPQCWRYEAITRGRRR` `:` `3lc0(A) : NMVETEPVQGCRDFPPEAMRCRRHLFDVFHATAKTFGFEEYDAPVLESEELYIRKAGEEITEQMFNFITKGGHRVALRPEMTPSLARLLLGKGRSLLLPAKWYSIPQCWRYEA-----rR` `________________________________________________________________________________________________________________________` `_______________________________________________215______________________________248_______________266___________________` `3hri(A) : EHYQWNMDIIGVKSVSSEVELVCAACTAMQSLGLSSKDVGVKINSRKILQTVVE------dKFAPVCVIV------pREEVVAQLAAIGLESNVVDAITSTLSLKTIDEIAQRIGEEHEA` `:` `3lc0(A) : EHYQWNMDIVGVKSVSAEVELVCAACWAMRSLGLSSKDVGIKVNSRKVLQTVVEQAGVTSDKFAPVCVIVDKMEKIPREEVEAQLAVLGLEPTVVDAITTTLSLKSIDEIAQRVGEEHEA` `_______________________________________________216______________________________249_______________267___________________` `________________________________________________________________________________________________________________________` `3hri(A) : VRELRDFITQIEAYGFGDWVIFDASVVRGLAYYTGIVFEGFDRDGNFRALCGGGRYDNLLTTYGSPTAVPCVGFGFGDCVIVELLNEKKLLPELHHVVDDLVIPFDETMRPHALSILRRL` `:` `3lc0(A) : VKELRQFFEQVEAYGYGDWVLFDASVVRGLAYYTGIVFEGFDREGKFRALCGGGRYDNLLTTYGSPTPIPCAGFGFGDCVIVELLQEKRLLPDIPHVVDDVVIPFDESMRPHALAVLRRL` `________________________________________________________________________________________________________________________` `____________________________________________________________` `3hri(A) : RDAGRSADIVFDKKKVVQAFNYADRIGALRAVLVAPDEWARGEVRVKMLRgIVLPVD**` `:` `3lc0(A) : RDAGRSADIILDKKKVVQAFNYADRVGAVRAVLVAPEEWERGEVQVKMLrGFAVPLDRLV` `____________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	18.1
Translation (A)	0.0
Closure (%)	75.9
Bending Residues ( green )	215 - 218 248 - 249 266 - 267
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

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