Isocitrate Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Isocitrate Dehydrogenase
  Conformer 1
(PDB) 		1sjs (A)
  Conformer 2
(PDB) 		1xkd (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 202 1.62   4 - 125   133 - 133   325 - 325   333 - 414
2 201 3.46   126 - 132   134 - 324   326 - 332

Sequence


           ________________________________________________________________________________________________________________________ 
 1sjs(A) : *****ESKVVVPAQGKKITLQNGKLNVPENPIIPYIEGDGIGVDVTPAMLKVVDAAVEKAYKGERKISWMEIYTGEKSTQVYGQDVWLPAETLDLIREYRVAIKGPLTTPVGGGIRSLNV 
         :                                                                                                                          
 1xkd(B) : SPPCTTEELSPPPGGSLVEYSGGSLRVPDNPVVAFIRGDGVGPEVVESALKVVDAAVKKV--gSRRIVWWELLAGHLAREKCGE--LLPKATLEGIRLARVALKGPLETPVGTGYRSLNV 
           ________________________________________________________________________________________________________________________ 

           ______125____132________________________________________________________________________________________________________ 
 1sjs(A) : ALRQELDLYICLRPVRYYQGTPSPVKHPELTDMVIFRENSEDIYAGIEWKADSADAEKVIKFLREEMGVKKIRFPEHCGIGIKPCSEEGTKRLVRAAIEYAIANDRDSVTLVHKGNIMKF 
         :                                                                                                                          
 1xkd(B) : AIRQALDLYANIRPVRYY-GQPAPHKYADRVDMVIFRENTEDVYAGIEWPHDSPEAARIRRFLAEEFGIS-IR--EDAGIGVKPISRFATRRLMERALEWALRNGNTVVTIMHKGNIMKY 
           ______132____139________________________________________________________________________________________________________ 

           ______________________________________________________________________________________324_____332_______________________ 
 1sjs(A) : TEGAFKDWGYQLAREEFGGELI-DGGPWLKVKNPNTGKEIVIKDVIADAFLQQILLRPAEYDVIACMNLNGDYISDALAAQVGGIGIAPGANIGDECALFEATHGTAPKYAGQDKVNPGS 
         :                                                                                                                          
 1xkd(B) : TEGAFMRWAYEVALEKFREHVVTEQEVQEKYGGVRPEGKILVNDRIADNMLQQIITRPWDYQVIVAPNLNGDYISDAASALVGGIGMAAGMNMGDGIAVAEPVHGTAPKYAGKDLINPSA 
           ______________________________________________________________________________________328_____336_______________________ 

           ___________________________________________________________________                                                      
 1sjs(A) : IILSAEMML-RHMGWTEAADLIVKGMEGAINAKTVTYDFERLMDGAKLLKCSEFGDAIIENM*****                                                      
         :                                                                                                                          
 1xkd(B) : EILSASLLIGEFMGWREVKSIVEYAIRKAVQSKKVTQDLARHMPGVQPLRTSEYTETLIAYIDEADL                                                      
           ___________________________________________________________________                                                      

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.


Show console


play backwards pause play forwards

Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		25.2
Translation
(A) 		-0.5
Closure
(%) 		89.4
Bending Residues
( green ) 		  125 - 126
  132 - 134
  324 - 326
  332 - 333
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

Download and extract PyMOL PML script file Download