DynDom - Protein Domain Motions

Transportin-1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Transportin-1
Conformer 1 (PDB)	1qbk (B)
Conformer 2 (PDB)	2ot8 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	648	5.25	146 - 147 151 - 163 185 - 887
2	93	5.47	68 - 145 148 - 150 172 - 184

Sequence

`________________________________________________________________________________________________________________________` `1qbk(B) : YEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGE` `:` `2ot8(A) : *******QGLQQILQLLKESQ---tTIQRTVQQKLEQLNQY--fNNYLIFVLTK-----ePTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGE` `________________________________________________________________________________________________________________________` `____________________145__150_______160_____________________184__________________________________________________________` `1qbk(B) : LQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSD---rPLNI-iPKFLQFFKHSSPKIRSHAVACVNQFIISRTQAL-lHIDSFTENLFALAGDEEPEVRKNVCRALV-l` `:` `2ot8(A) : LQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVML` `____________________145__150_______160_____________________184__________________________________________________________` `________________________________________________________________________________________________________________________` `1qbk(B) : LEVRMDRLLPH-hNIVEY-lQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNG-kYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDdDDDDEIDDD` `:` `2ot8(A) : LEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLK------------------------------------------d` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1qbk(B) : DTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGC-qG-iPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPL-tELLK` `:` `2ot8(A) : DTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLK` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1qbk(B) : RILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQl--pPLIQKWN-lKDEDKDLFPLLECLSSVATALQSGFLPYCEP` `:` `2ot8(A) : RILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEP` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1qbk(B) : VYQRCVNLVQKTLAQA-lNNAQPDQYEAPDKDF-iVALDLLSGLAEGLGGNIEQLVARSNILTL-yQC-qDK-pEVRQSSFALLGDLTKACFQHVKPCIADF-pILGTNLNPEFISVCNN` `:` `2ot8(A) : VYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNN` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1qbk(B) : ATWAIGEISIQ-gIE-qPYIP-vLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAP-lQQFIRPWCTSLRNIRDNEEKDSAFRGICT-iSVNPSGVIQDFIFFCDAVASWINPKD` `:` `2ot8(A) : ATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKD` `________________________________________________________________________________________________________________________` `___________________________________________` `1qbk(B) : DLRD-fCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV` `:` `2ot8(A) : DLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV` `___________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	26.8
Translation (A)	0.8
Closure (%)	39.1
Bending Residues ( green )	145 - 148 150 - 151 160 - 172 184 - 191
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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