Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Metabotropic Glutamate Receptor Subtype 1
  Conformer 1
(PDB) 		1ewt (B)
  Conformer 2
(PDB) 		1ewv (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 281 0.74   38 - 211   341 - 476
2 163 0.76   212 - 340   477 - 510

Sequence


           ________________________________________________________________________________________________________________________ 
 1ewt(B) : QRSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRDSLISIRkPIAGVIGPGSSSVAIQVQNLLQ 
         :                                                                                                                          
 1ewv(B) : *RSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIR-------kPIAGVIGPGSSSVAIQVQNLLQ 
           ________________________________________________________________________________________________________________________ 

           _______________________________210______________________________________________________________________________________ 
 1ewt(B) : LFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTV 
         :                                                                                                                          
 1ewv(B) : LFDIPQIAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTV 
           _______________________________210______________________________________________________________________________________ 

           _________________________________________340____________________________________________________________________________ 
 1ewt(B) : RGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINA 
         :                                                                                                                          
 1ewv(B) : RGLLSAMRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEENYVQDSKMGFVINA 
           _________________________________________340____________________________________________________________________________ 

           ________________________________________________________475_____________________________________                         
 1ewt(B) : IYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKI                         
         :                                                                                                                          
 1ewv(B) : IYAMAHGLQNMHHALCPGHVGLCDAMKPIDGRKLLDFLIKSSFVGVSGEEVWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKI                         
           ________________________________________________________475_____________________________________                         

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		12.2
Translation
(A) 		-0.8
Closure
(%) 		84.2
Bending Residues
( green ) 		  210 - 212
  340 - 341
  475 - 477
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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