DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor Subtype 1
Conformer 1 (PDB)	3lmk (A)
Conformer 2 (PDB)	6n52 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	267	0.89	28 - 194 332 - 464
2	166	0.94	195 - 331 465 - 493

Sequence

`________________________________________________________________________________________________________________________` `3lmk(A) : RRVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRD------------kPIVGVIGPGSSSVAIQ` `:` `6n52(A) : RVVAHMPGDIIIGALFSVHHQPTVDKVHERKCGAVREQYGIQRVEAMLHTLERINSDPTLLPNITLGCEIRDSCWHSAVALEQSIEFIRDSLISSEEsFRSKKPIVGVIGPGSSSVAIQ` `________________________________________________________________________________________________________________________` `__________________________________194___________________________________________________________________________________` `3lmk(A) : VQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGISIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACF` `:` `6n52(A) : VQNLLQLFNIPQIAYSATSMDLSDKTLFKYFMRVVPSDAQQARAMVDIVKRYNWTYVSAVHTEGNYGESGMEAFKDMSAKEGICIAHSYKIYSNAGEQSFDKLLKKLTSHLPKARVVACF` `__________________________________194___________________________________________________________________________________` `___________________________________________________331__________________________________________________________________` `3lmk(A) : CEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEG--------nKTCNSSLTLKTHHVQDSKM` `:` `6n52(A) : CEGMTVRGLLMAMRRLGLAGEFLLLGSDGWADRYDVTDGYQREAVGGITIKLQSPDVKWFDDYYLKLRPETNHRNPWFQEFWQHRFQCRLEGFPQENSKYNKTCNSSLTLKTHHVQDSKM` `___________________________________________________331__________________________________________________________________` `________________________________________________________________464_____________________________________________________` `3lmk(A) : GFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMD*******************` `:` `6n52(A) : GFVINAIYSMAYGLHNMQMSLCPGYAGLCDAMKPIDGRKLLESLMKTNFTGVSGDTILFDENGDSPGRYEIMNFKEMGKDYFDYINVGSWDNGELKMDDDEVWSKKSNIIRSVCSEPCEK` `________________________________________________________________464_____________________________________________________` `________________________________________________________________________________________________________________________` `3lmk(A) : ********************************************************************************************************************` `:` `6n52(A) : GQIKVIRKGEVSCCWTCTPCKENEYVFDEYTCKACQLGSWPTDDLTGCDLIPVQYLRWGDPEPIAAVVFACLGLLATLFVTVVFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIA` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `3lmk(A) : ********************************************************************************************************************` `:` `6n52(A) : KPKQIYCYLQRIGIGLSPAMSYSALVTKTNRIaCAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIREVYLICNTTNLGVVTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFT` `________________________________________________________________________________________________________________________` `_______________________________________________________` `3lmk(A) : *****************************************************` `:` `6n52(A) : MYTTCIIWLAFVPIYFGSNYKIITMCFSVSLSATVALGCMFVPKVYIILAKPERN` `_______________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	30.4
Translation (A)	0.4
Closure (%)	100.0
Bending Residues ( green )	194 - 196 331 - 333 464 - 466
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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