Methylenetetrahydrofolate Dehydrogenase/cyclohydrolase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Methylenetetrahydrofolate Dehydrogenase/cyclohydrolase
  Conformer 1
(PDB) 		1dib (A)
  Conformer 2
(PDB) 		1a4i (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 156 0.48   4 - 15   126 - 279
2 124 0.38   16 - 125   280 - 293

Sequence


           ____________15__________________________________________________________________________________________________________ 
 1dib(A) : APAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPE 
         :                                                                                                                          
 1a4i(B) : APAEILNGKEISAQIRARLKNQVTQLKEQVPGFTPRLAILQVGNRDDSNLYINVKLKAAEEIGIKATHIKLPRTTTESEVMKYITSLNEDSTVHGFLVQLPLDSENSINTEEVINAIAPE 
           ____________15__________________________________________________________________________________________________________ 

           _125____________________________________________________________________________________________________________________ 
 1dib(A) : KDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINY- 
         :                                                                                                                          
 1a4i(B) : KDVDGLTSINAGRLARGDLNDCFIPCTPKGCLELIKETGVPIAGRHAVVVGRSKIVGAPMHDLLLWNNATVTTCHSKTAHLDEEVNKGDILVVATGQPEMVKGEWIKPGAIVIDCGINYV 
           _125____________________________________________________________________________________________________________________ 

           ___________________________________279_________________                                                                  
 1dib(A) : ---------kVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLE                                                                  
         :                                                                                                                          
 1a4i(B) : PDDKKPNGRKVVGDVAYDEAKERASFITPVPGGVGPMTVAMLMQSTVESAKRFLE                                                                  
           ___________________________________279_________________                                                                  

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		13.1
Translation
(A) 		0.4
Closure
(%) 		98.1
Bending Residues
( green ) 		  15 - 18
  125 - 126
  279 - 281
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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