Mitogen-Activated Protein Kinase 14

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Mitogen-Activated Protein Kinase 14
  Conformer 1
(PDB) 		3lfb (A)
  Conformer 2
(PDB) 		3gcp (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 202 1.25   79 - 83   109 - 318
2 126 0.63   6 - 78   84 - 108   319 - 350

Sequence


           _________________________________________________________________________78___83_____________________107________________ 
 3lfb(A) : ERPTFYRQELNKTIWEVPERYQNLSPVGS----sVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKSQKLT 
         :                                                                                                                          
 3gcp(A) : ERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKSQKLT 
           _________________________________________________________________________78___83_____________________107________________ 

           ________________________________________________________________________________________________________________________ 
 3lfb(A) : DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDSELKILDFG-aTRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 
         :                                                                                                                          
 3gcp(A) : DDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDSELKILDFGLCtRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESA 
           ________________________________________________________________________________________________________________________ 

           ____________________________________________________________318___________________________________                       
 3lfb(A) : RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSLESRDLLIDEWKSLTYDEVISFVPPPL                       
         :                                                                                                                          
 3gcp(A) : RNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSLESRDLLIDEWKSLTYDEVISFVPPP*                       
           ____________________________________________________________318___________________________________                       

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		8.4
Translation
(A) 		-0.2
Closure
(%) 		96.3
Bending Residues
( green ) 		  78 - 79
  83 - 84
  107 - 112
  318 - 319
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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