Thymidylate Synthase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Thymidylate Synthase
  Conformer 1
(PDB) 		1b02 (A)
  Conformer 2
(PDB) 		1bko (C)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 206 0.67   5 - 9   43 - 46   51 - 181   186 - 188   194 - 222   234 - 267
2 67 1.09   4 - 4   10 - 42   47 - 50   182 - 185   189 - 193   223 - 233   268 - 276

Sequence


           ___4___8________________________________42__46__50______________________________________________________________________ 
 1b02(A) : MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVISKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDGTIGHAYGFQLGKKNRSLN 
         :                                                                                                                          
 1bko(C) : *TQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVISKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDGTIGHAYGFQLGKKNRSLN 
           ___4___8________________________________42__46__50______________________________________________________________________ 

           __________________________________________________________181_185_____193__________________________222________233_______ 
 1b02(A) : GEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQF 
         :                                                                                                                          
 1bko(C) : GEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTPCVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNIGDCHVYTRHIDNLKIQMEREQF 
           __________________________________________________________181_185_____193__________________________222________233_______ 

           ________________________267____________                                                                                  
 1b02(A) : EAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVAV                                                                                  
         :                                                                                                                          
 1bko(C) : EAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFEVAV                                                                                  
           ________________________267____________                                                                                  

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		9.6
Translation
(A) 		0.2
Closure
(%) 		81.7
Bending Residues
( green ) 		  4 - 5
  8 - 10
  42 - 43
  46 - 47
  50 - 51
  181 - 182
  185 - 186
  188 - 189
  193 - 194
  222 - 223
  233 - 235
  267 - 268
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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