DynDom - Protein Domain Motions

Vitamin D Hydroxylase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Vitamin D Hydroxylase
Conformer 1 (PDB)	3a51 (A)
Conformer 2 (PDB)	3a4h (A)
Window Length	13
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	312	0.75	10 - 148 224 - 236 238 - 397
2	76	2.87	149 - 223 237 - 237

Sequence

`________________________________________________________________________________________________________________________` `3a51(A) : ALTTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHRLPEDQRADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEI` `:` `3a4h(A) : **TTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHTLPEDQRADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEI` `________________________________________________________________________________________________________________________` `______________________146__________________________________________________________________________223__________________` `3a51(A) : ADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGLPAEDRDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDMDGDRLSQEELVAMAMLLLIAGHETT` `:` `3a4h(A) : ADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGVPAEDRDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDEDGDRLSQEELVAMAMLLLIAGHETT` `______________________146__________________________________________________________________________223__________________` `________________________________________________________________________________________________________________________` `3a51(A) : VNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVFFGHGIHFCLGAQLARLEGRVAI` `:` `3a4h(A) : VNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVFFGHGIHFCLGAQLARLEGRVAI` `________________________________________________________________________________________________________________________` `__________________________________________` `3a51(A) : GRLFADRPELALAVGLDELVYRRSTLVRGLSRMPVTMGPRSA` `:` `3a4h(A) : GRLFADRPELALAVGLDELVYRESTLVRGLSRMPVTMGPRSA` `__________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	13.9
Translation (A)	-3.1
Closure (%)	70.5
Bending Residues ( green )	146 - 149 223 - 243
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

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