Alpha-2,3/2,6-Sialyltransferase/sialidase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Alpha-2,3/2,6-Sialyltransferase/sialidase
  Conformer 1
(PDB) 		2ii6 (A)
  Conformer 2
(PDB) 		2ilv (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 220 0.64   27 - 246
2 154 2.51   247 - 410

Sequence


           ________________________________________________________________________________________________________________________ 
 2ii6(A) : MKTITLYLDPASLPALNQLMDFTQNNEDKTHPRIFGLSRFKIPDNIITQYQNIHFVELKDNRPTEALFTILDQYPGNIELNIHLNIAHSVQLIRPILAYRFKHLDRVSIQQLNLYDNGSM 
         :                                                                                                                          
 2ilv(A) : MKTITLYLDPASLPALNQLMDFTQNNEDKTHPRIFGLSRFKIPDNIITQYQNIHFVELKDNRPTEALFTILDQYPGNIELNIHLNIAHSVQLIRPILAYRFKHLDRVSIQQLNLYDDGSM 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________________________________________________________246__________________ 
 2ii6(A) : EYVDLEKEENKDISAEIKQAEKQLSHYLLTGKIKFDNPTIARYVWQSAFPVKYHFLSTDYFEKAEFLQPLKEYLAENYQKMDWTAYQQLTPEQQAFYLTLVGFNDEVKQSLEVQQAKFIF 
         :                                                                                                                          
 2ilv(A) : EYVDLEKEENKDISAEIKQAEKQLSHYLLTGKIKFDNPTIARYVWQSAFPVKYHFLSTDYFEKAEFLQPLKEYLAENYQKMDWTAYQQLTPEQQAFYLTLVGFNDEVKQSLEVQQAKFIF 
           ___________________________________________________________________________________________________246__________________ 

           ________________________________________________________________________________________________________________________ 
 2ii6(A) : TGTTTWEGNTDVREYYAQQQLNLLNHFTQAEGDLFIGDHYKIYFKGHPRGGEINDYILNNAKNITNIPANISFEVLMMTGLLPDKVGGVASSLYFSLPKEKISHIIFTSNKQVKSKEDAL 
         :                                                                                                                          
 2ilv(A) : TGTTTWEGNTDVREYYAQQQLNLLNHFTQAEGDLFIGDHYKIYFKGHPRGGEINDYILNNAKNITNIPANISFEVLMMTGLLPDKVGGVASSLYFSLPKEKISHIIFT----------aL 
           ________________________________________________________________________________________________________________________ 

           _________________________________                                                                                        
 2ii6(A) : NNPYVKVMRRLGIIDESQVIFWDSLKQLGGGLE                                                                                        
         :                                                                                                                          
 2ilv(A) : NNPYVKVMRRLGIIDESQVIFWDSLKQL*****                                                                                        
           _________________________________                                                                                        

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		25.7
Translation
(A) 		0.0
Closure
(%) 		96.3
Bending Residues
( green ) 		  246 - 247
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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