Fibroblast Growth Factor Receptor 3

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Fibroblast Growth Factor Receptor 3
  Conformer 1
(PDB) 		4k33 (A)
  Conformer 2
(PDB) 		6yi8 (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 174 2.23   533 - 539   558 - 633   639 - 753
2 95 1.54   461 - 532   540 - 557   634 - 638

Sequence


           ________________________________________________________________________532____539_______________557____________________ 
 4k33(A) : *LPADPKWELSRARLTLGKPLGEGAFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDY 
         :                                                                                                                          
 6yi8(A) : DLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDL 
           ________________________________________________________________________527____534_______________552____________________ 

           _________________________________________________633____________________________________________________________________ 
 4k33(A) : SFDTSeQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKETTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGIPVE 
         :                                                                                                                          
 6yi8(A) : S-----pLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLAr---------------LPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVE 
           _________________________________________________628____________________________________________________________________ 

           _________________________________________________________                                                                
 4k33(A) : ELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDLDRVLTVT***                                                                
         :                                                                                                                          
 6yi8(A) : ELFSLLREGHRMDRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEE                                                                
           _________________________________________________________                                                                

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		17.2
Translation
(A) 		-0.6
Closure
(%) 		74.7
Bending Residues
( green ) 		  532 - 533
  539 - 540
  557 - 558
  633 - 634
  636 - 657
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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