DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor Subtype 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor Subtype 1
Conformer 1 (PDB)	2e4u (A)
Conformer 2 (PDB)	2e4y (A)
Window Length	11
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	449	0.47	35 - 509
2	53	0.51	510 - 562

Sequence

`________________________________________________________________________________________________________________________` `2e4u(A) : RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLiPLLIAGVIGGSYSSVSIQVANLLRLFQIPQI` `:` `2e4y(A) : RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLiPLLIAGVIGGSYSSVSIQVANLLRLFQIPQI` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2e4u(A) : SYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAAN` `:` `2e4y(A) : SYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAAN` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2e4u(A) : RVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQ------qVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQR` `:` `2e4y(A) : RVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQR` `________________________________________________________________________________________________________________________` `_________________________________________________________________________________________________509____________________` `2e4u(A) : TLCPQTTKLCDAMKILDGKKLYKEYLLKIQFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCW` `:` `2e4y(A) : TLCPQTTKLCDAMKILDGKKLYKEYLLKIQFTAPFNPNKGADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCW` `_________________________________________________________________________________________________509____________________` `______________________________________` `2e4u(A) : ICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPE` `:` `2e4y(A) : ICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPE` `______________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	6.4
Translation (A)	1.0
Closure (%)	80.6
Bending Residues ( green )	509 - 510
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

PyMOL Script

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