DynDom - Protein Domain Motions

Mu-Like Calpain

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Mu-Like Calpain
Conformer 1 (PDB)	1qxp (A)
Conformer 2 (PDB)	2ary (A)
Window Length	9
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	188	2.74	27 - 204 285 - 286 290 - 292 336 - 340
2	113	3.2	205 - 284 287 - 289 293 - 335

Sequence

`________________________________________________________________________________________________________________________` `1qxp(A) : AGIAMKLAKDREAAEGLGSHERAIKYLNQDYETLRNECLEAGALFQDPAFPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDSWLLAAIASLTLNETIL` `:` `2ary(A) : *******************NAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLL` `________________________________________________________________________________________________________________________` `________________________________________________________________________________204_____________________________________` `1qxp(A) : HRVVPYGQSFQEGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCS` `:` `2ary(A) : HRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCS` `________________________________________________________________________________214_____________________________________` `________________________________________284__289___________________________________________335__________________________` `1qxp(A) : INI---------tFKNL---hAYSVTDAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSnSY-EWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNLTPlKSRTLRNWNTTFYEG` `:` `2ary(A) : IDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLT*************` `________________________________________294__299___________________________________________345__________________________` `________________________________________________________________________________________________________________________` `1qxp(A) : TWRRGSTAGGCRNYPATFWVNPQFKIRLEEVDDsRESGCSFLLALMQKdMETIGFAVYQVPRELvHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRF` `:` `2ary(A) : ********************************************************************************************************************` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1qxp(A) : FSEKKAGTQELDDQIQANLPsKLAGDDMEISVKELQTILNrTNGFSLESCRSMVNLMDRnGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMAIEAAGFKLPCQLHQVIVAR` `:` `2ary(A) : ********************************************************************************************************************` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1qxp(A) : FADDELIIDFDNFVRCLVRLEILFKIFKQLDPENTGTIQLDLISWLSFSVLmHYSNIfVQLAGDDMEVSATELMNILNKhPDLKgFGIDTCRSMVAVMDSDTTGKLGFEEFKYLWNNIKK` `:` `2ary(A) : ********************************************************************************************************************` `________________________________________________________________________________________________________________________` `____________________________________________________________________________` `1qxp(A) : WQGIYtDRSGpGAFEAAGFHLNQHIYSeTGNMDFDNFISCLVRLDAMFRAFRSLDKNGTGQIQVNIQEWLQLTMYS` `:` `2ary(A) : **************************************************************************` `____________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	24.1
Translation (A)	-0.1
Closure (%)	58.5
Bending Residues ( green )	204 - 205 284 - 287 289 - 290 292 - 293 335 - 336
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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