DynDom - Protein Domain Motions

Smoothened Homolog,soluble Cytochrome B562,smoothened Homolog

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Smoothened Homolog,soluble Cytochrome B562,smoothened Homolog
Conformer 1 (PDB)	5l7i (A)
Conformer 2 (PDB)	5l7d (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	457	2.04	60 - 428 1127 - 1128 1131 - 549
2	102	0.71	1011 - 1126 1129 - 1130

Sequence

`________________________________________________________________________________________________________________________` `5l7i(A) : PPPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPE` `:` `5l7d(A) : PPPLSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPE` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `5l7i(A) : GCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR` `:` `5l7d(A) : GCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCR` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `5l7i(A) : ADGTMRLGEPTSNETLSCVIIFVIVYYALMAGFVWFVVLTYAWHTSF-----lSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI` `:` `5l7d(A) : ADGTMRLGEPTSNETLSCVIIFVIVYYALMAGFVWFVVLTYAWHTSFKALqPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI` `________________________________________________________________________________________________________________________` `____427_________________________________________________________________________________________________________1126____` `5l7i(A) : RGVMTLFSARRQLADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQK--------kDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLERARSTLSK` `:` `5l7d(A) : RGVMTLFSARRQLADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQKATPPsPEMKDFRHGFDILVGQIDDALKLANEGKVKEAQAAAEQLKTTRNAYIQKYLERARSTLSK` `____427_________________________________________________________________________________________________________1126____` `_____________________________________________________________________________________________________________` `5l7i(A) : INETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVT----------dCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCR*` `:` `5l7d(A) : INETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLT` `_____________________________________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	22.3
Translation (A)	1.9
Closure (%)	27.7
Bending Residues ( green )	427 - 1011 1126 - 1131
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification:

No Contacts

PyMOL Script

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