Mitogen-Activated Protein Kinase 8

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Mitogen-Activated Protein Kinase 8
  Conformer 1
(PDB) 		1ukh (A)
  Conformer 2
(PDB) 		4l7f (A)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 208 1.27   81 - 86   111 - 334
2 107 2.29   12 - 80   87 - 110   335 - 360

Sequence


           __________________________________________________________________________80____86_____________________110______________ 
 1ukh(A) : ****NFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELD 
         :                                                                                                                          
 4l7f(A) : SLDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELD 
           __________________________________________________________________________80____86_____________________110______________ 

           ________________________________________________________________________________________________________________________ 
 1ukh(A) : HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL----yYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVR 
         :                                                                                                                          
 4l7f(A) : HERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLvVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVR 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________________________________334_____________________________________       
 1ukh(A) : TYVENRPKYAGYSFEKLFPDVLFP-----nKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKi------------EEWKELIYKEVMDL********       
         :                                                                                                                          
 4l7f(A) : TYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDWRKGIITIT       
           __________________________________________________________________________334_____________________________________       

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		13.9
Translation
(A) 		-1.9
Closure
(%) 		95.9
Bending Residues
( green ) 		  80 - 81
  86 - 87
  110 - 111
  334 - 350
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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