Mitogen-Activated Protein Kinase 8

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Mitogen-Activated Protein Kinase 8
  Conformer 1
(PDB) 		1ukh (A)
  Conformer 2
(PDB) 		3o17 (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 213 1.37   77 - 86   111 - 335
2 104 2.26   11 - 76   87 - 110   336 - 361

Sequence


           ____________________________________________________________________76________86_____________________110________________ 
 1ukh(A) : **NFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHE 
         :                                                                                                                          
 3o17(B) : DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHE 
           ____________________________________________________________________76________86_____________________110________________ 

           ________________________________________________________________________________________________________________________ 
 1ukh(A) : RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-----------------yYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCP 
         :                                                                                                                          
 3o17(B) : RMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMEPEVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCP 
           ________________________________________________________________________________________________________________________ 

           ______________________________________________________________________________________335____________________________    
 1ukh(A) : EFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFP-----nKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKi------------EEWKELIYKEVMDL    
         :                                                                                                                          
 3o17(B) : AFMKKLQPTVRNYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDL    
           ______________________________________________________________________________________335____________________________    

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		17.3
Translation
(A) 		-0.9
Closure
(%) 		100.0
Bending Residues
( green ) 		  76 - 77
  86 - 87
  110 - 111
  335 - 349
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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