Mitogen-Activated Protein Kinase 8

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Mitogen-Activated Protein Kinase 8
  Conformer 1
(PDB) 		1ukh (A)
  Conformer 2
(PDB) 		2xrw (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 209 0.7   82 - 86   110 - 335
2 108 2.39   11 - 81   87 - 109   336 - 361

Sequence


           _______________________________________________________________________________81___86____________________109___________ 
 1ukh(A) : ********NFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 
         :                                                                                                                          
 2xrw(A) : GSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ 
           _______________________________________________________________________________81___86____________________109___________ 

           ________________________________________________________________________________________________________________________ 
 1ukh(A) : MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-yYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTV 
         :                                                                                                                          
 2xrw(A) : MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLrYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQlGTPCPEFMKKLQPTV 
           ________________________________________________________________________________________________________________________ 

           ___________________________________________________________________________334_______________________________            
 1ukh(A) : RTYVENRPKYAGYSFEKLFPDVLFP-----nKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKi------------EEWKELIYKEVMDL**            
         :                                                                                                                          
 2xrw(A) : RTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEH            
           ___________________________________________________________________________334_______________________________            

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		18.6
Translation
(A) 		-1.2
Closure
(%) 		95.4
Bending Residues
( green ) 		  81 - 82
  86 - 87
  109 - 110
  334 - 349
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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