DynDom - Protein Domain Motions

Serine Hydroxymethyltransferase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Serine Hydroxymethyltransferase
Conformer 1 (PDB)	6uxi (A)
Conformer 2 (PDB)	6uxj (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	326	0.45	2 - 124 133 - 159 163 - 188 192 - 321 391 - 400 454 - 468
2	131	0.44	125 - 132 160 - 162 189 - 191 322 - 390 401 - 453

Sequence

`________________________________________________________________________________________________________________________` `6uxi(A) : SHMDPVSVWGNTPLATVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYGGNEYIDQIENLCRSRALQAFHLDAQSWGVNVQPYSGSPANFAAYTAVL` `:` `6uxj(A) : *HMDPVSVWGNTPLATVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYGGNEYIDQIENLCRSRALQAFHLDAQSWGVNVQPYSGSPANFAAYTAVL` `________________________________________________________________________________________________________________________` `___124_____132________________________159__________________________188__________________________________________________` `6uxi(A) : NPHDRIMGLDLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSTTGYIDYDRLEEKALDFRPKLIICGGSAYPRDWDYKRFREVADKCGALLLCDMAHTSGLVAAQEVNSPFEYCDIV` `:` `6uxj(A) : NPHDRIMGLDLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSTTGYIDYDRLEEKALDFRPKLIICGGSAYPRDWDYKRFREVADKCGALLLCDMAHTSGLVAAQEVNSPFEYCDIV` `___124_____132________________________159__________________________188__________________________________________________` `________________________________________________________________________________321_____________________________________` `6uxi(A) : TTTTHKSLRGPRAGMIFYRKGPKPP-----eNAVYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAASPGFKAYAKQVKANAVALGKYLMGKGYSLVTGGTENHLVLWDLRPLGLTGN` `:` `6uxj(A) : TTTTHKSLRGPRAGMIFYRKGPKPPKKGQPENAVYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAASPGFKAYAKQVKANAVALGKYLMGKGYSLVTGGTENHLVLWDLRPLGLTGN` `________________________________________________________________________________321_____________________________________` `_____________________________390_______400__________________________________________________453_________________` `6uxi(A) : KVEKLCDLCNITVNKNAVFG-----aPGGVRIGAPAMTSRGLVEKDFEQIGEFLHRAVTLTLEIQKEHGKLLKDFNKGLVNNKAIEDLKADVEKFSALFDMPGFLVSEMKYK` `:` `6uxj(A) : KVEKLCDLCNITVNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEQIGEFLHRAVTLTLEIQKEHGKLLKDFNKGLVNNKAIEDLKADVEKFSALFDMPGFLVSEMKYK` `_____________________________390_______400__________________________________________________453_________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	3.7
Translation (A)	0.0
Closure (%)	79.1
Bending Residues ( green )	124 - 125 132 - 133 159 - 163 188 - 189 191 - 192 321 - 322 390 - 391 400 - 401 453 - 454
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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