DynDom - Protein Domain Motions

Alpha-1-Antitrypsin

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Alpha-1-Antitrypsin
Conformer 1 (PDB)	5io1 (A)
Conformer 2 (PDB)	3t1p (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	329	9.77	26 - 360
2	32	0.7	361 - 392

Sequence

`________________________________________________________________________________________________________________________` `5io1(A) : NKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAF` `:` `3t1p(A) : NKITPNLAEFAFSLYRQLAHQSNSTNIFFSPVSIATAFAMLSLGTKADTHDEILEGLNFNLTEIPEAQIHEGFQELLRTLNQPDSQLQLTTGNGLFLSEGLKLVDKFLEDVKKLYHSEAF` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `5io1(A) : TVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHCKKLSSWVLLMKYLGNATAIFFLPDEGKLQHL` `:` `3t1p(A) : TVNFGDTEEAKKQINDYVEKGTQGKIVDLVKELDRDTVFALVNYIFFKGKWERPFEVKDTEEEDFHVDQVTTVKVPMMKRLGMFNIQHSKKLSSWVLLMKYLGNATAIFFLPDEGKLQHL` `________________________________________________________________________________________________________________________` `_____________________________________________________________________________343________________________________________` `5io1(A) : ENELTHDIITKFLENEDRRSASLHLPKLSITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLTIDKKGCE------lEAIPRSIPPEVKFNKPFVFLMIEQNTKSPL` `:` `3t1p(A) : ENELTHDIITKFLENEDRRSASLHLPKLCITGTYDLKSVLGQLGITKVFSNGADLSGVTEEAPLKLSKAVHKAVLCIDEKGTEAAGAMFLEAIPRSIPPEVKFNKPFVFLMIEQNTKSPL` `_____________________________________________________________________________343________________________________________` `___________` `5io1(A) : FMGKVVNPTQK` `:` `3t1p(A) : FMGKVVNPTQK` `___________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	121.2
Translation (A)	1.4
Closure (%)	98.0
Bending Residues ( green )	343 - 361
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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