Human Adenosine A2a Receptor/t4 Lysozyme Chimera

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Human Adenosine A2a Receptor/t4 Lysozyme Chimera
  Conformer 1
(PDB) 		3eml (A)
  Conformer 2
(PDB) 		2ydo (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 244 1.78   8 - 207   245 - 282   292 - 304
2 22 1.14   230 - 244   285 - 291

Sequence


           ________________________________________________________________________________________________________________________ 
 3eml(A) : IMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAK 
         :                                                                                                                          
 2ydo(A) : ***SSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSAAAADILVGVLAIPFAIAISTGFCAACHGCLFIACFVLVLTASSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAK 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________205_____________________________________ 
 3eml(A) : GIIAICWVLSFAIGLTPMLGWNNCGQ-------sQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLNIFEMLRIDEGLRLKIYKDTEGYYTIGIGHLLTK 
         :                                                                                                                          
 2ydo(A) : GIIAICWVLSFAIGLTPMLGWNNCGQPKEGKAHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLK--------------------------------- 
           ________________________________________________________________________________205_____________________________________ 

           ________________________________________________________________________________________________________________________ 
 3eml(A) : SPSLNAAKSELDKAIGRNTNGVITKDEAEKLFNQDVDAAVRGILRNAKLKPVYDSLDAVRRAALINMVFQMGETGVAGFTNSLRMLQQKRWDEAAVNLAKSRWYNQTPNRAKRVITTFRT 
         :                                                                                                                          
 2ydo(A) : ---------------------------------------------------------------------QM------------------------------------------------- 
           ________________________________________________________________________________________________________________________ 

           __________________________244___________________________________282_____290__________________________________            
 3eml(A) : GTWDAYRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQ**************            
         :                                                                                                                          
 2ydo(A) : ------EStLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAAAENLYF            
           __________________________244___________________________________282_____290__________________________________            

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		30.8
Translation
(A) 		0.8
Closure
(%) 		36.1
Bending Residues
( green ) 		  205 - 230
  244 - 245
  282 - 285
  290 - 292
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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