Liver Alcohol Dehydrogenase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Liver Alcohol Dehydrogenase
  Conformer 1
(PDB) 		8adh (A)
  Conformer 2
(PDB) 		2ohx (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 239 0.88   3 - 176   291 - 291   293 - 300   316 - 367   369 - 372
2 131 0.36   177 - 290   292 - 292   301 - 315   368 - 368

Sequence


           ________________________________________________________________________________________________________________________ 
 8adh(A) : STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPR 
         :                                                                                                                          
 2ohx(A) : STAGKVIKCKAAVLWEEKKPFSIEEVEVAPPKAHEVRIKMVATGICRSDDHVVSGTLVTPLPVIAGHEAAGIVESIGEGVTTVRPGDKVIPLFTPQCGKCRVCKHPEGNFCLKNDLSMPR 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________176________________________________________________________________ 
 8adh(A) : GTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATEC 
         :                                                                                                                          
 2ohx(A) : GTMQDGTSRFTCRGKPIHHFLGTSTFSQYTVVDEISVAKIDAASPLEKVCLIGCGFSTGYGSAVKVAKVTQGSTCAVFGLGGVGLSVIMGCKAAGAARIIGVDINKDKFAKAKEVGATEC 
           _____________________________________________________176________________________________________________________________ 

           _______________________________________________290______________________315_____________________________________________ 
 8adh(A) : VNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFD 
         :                                                                                                                          
 2ohx(A) : VNPQDYKKPIQEVLTEMSNGGVDFSFEVIGRLDTMVTALSCCQEAYGVSVIVGVPPDSQNLSMNPMLLLSGRTWKGAIFGGFKSKDSVPKLVADFMAKKFALDPLITHVLPFEKINEGFD 
           _______________________________________________290______________________315_____________________________________________ 

           ____367_______                                                                                                           
 8adh(A) : LLRSGESIRTILTF                                                                                                           
         :                                                                                                                          
 2ohx(A) : LLRSGESIRTILTF                                                                                                           
           ____367_______                                                                                                           

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		9.8
Translation
(A) 		-0.1
Closure
(%) 		95.5
Bending Residues
( green ) 		  176 - 177
  290 - 301
  315 - 317
  367 - 369
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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