Proto-Oncogene Serine/threonine-Protein Kinase Pim-1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Proto-Oncogene Serine/threonine-Protein Kinase Pim-1
  Conformer 1
(PDB) 		1xws (A)
  Conformer 2
(PDB) 		2bzh (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 198 0.2   89 - 104   122 - 303
2 71 0.24   35 - 88   105 - 121

Sequence


           _______________________________________________________88_____________104______________121______________________________ 
 1xws(A) : *PLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 
         :                                                                                                                          
 2bzh(B) : EPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQV 
           _______________________________________________________88_____________104______________121______________________________ 

           ________________________________________________________________________________________________________________________ 
 1xws(A) : LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCL 
         :                                                                                                                          
 2bzh(B) : LEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIGGQVFFRQRVSSECQHLIRWCL 
           ________________________________________________________________________________________________________________________ 

           ___________________________________                                                                                      
 1xws(A) : ALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLH*                                                                                      
         :                                                                                                                          
 2bzh(B) : ALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHS                                                                                      
           ___________________________________                                                                                      

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		4.9
Translation
(A) 		0.2
Closure
(%) 		100.0
Bending Residues
( green ) 		  88 - 89
  104 - 105
  121 - 122
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

PyMOL Script

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