P21-Activated Kinase 4

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name P21-Activated Kinase 4
  Conformer 1
(PDB) 		2j0i (A)
  Conformer 2
(PDB) 		2q0n (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 216 0.6   317 - 327   336 - 341   370 - 378   397 - 587
2 69 0.95   302 - 316   328 - 335   342 - 369   379 - 396

Sequence


           ________________316________327_____335__340_________________________368_______378_______________396_____________________ 
 2j0i(A) : **SHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQI 
         :                                                                                                                          
 2q0n(A) : RVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQI 
           ________________316________327_____335__340_________________________368_______378_______________396_____________________ 

           ________________________________________________________________________________________________________________________ 
 2j0i(A) : AAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKlVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNL 
         :                                                                                                                          
 2q0n(A) : AAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKlVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNL 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________                                                                    
 2j0i(A) : HKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNR**                                                                    
         :                                                                                                                          
 2q0n(A) : HKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR                                                                    
           _____________________________________________________                                                                    

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		11.9
Translation
(A) 		0.6
Closure
(%) 		40.1
Bending Residues
( green ) 		  316 - 321
  327 - 328
  335 - 336
  340 - 342
  368 - 376
  378 - 379
  396 - 400
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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