DynDom - Protein Domain Motions

Pyrimidine Nucleoside Phosphorylase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Pyrimidine Nucleoside Phosphorylase
Conformer 1 (PDB)	1brw (B)
Conformer 2 (PDB)	1brw (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	315	0.77	1069 - 1151 1193 - 1216 1222 - 1429
2	112	1.13	1003 - 1068 1152 - 1192 1217 - 1221

Sequence

`______________________________________________________________1066______________________________________________________` `1brw(B) : MRMVDLIAKKRDGKALTKEEIEWIVRGYTNGDIPDYQMSALAMAIYFRGMTEEETAALTMAMVQSGEMLDLSSIRGVKVDKHSTGGVGDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGT` `:` `1brw(A) : MRMVDLIAKKRDGKALTKEEIEWIVRGYTNGDIPDYQMSALAMAIYFRGMTEEETAALTMAMVQSGEMLDLSSIRGVKVDKHSTGGVGDTTTLVLGPLVASVGVPVAKMSGRGLGHTGGT` `________________________________________________________________66______________________________________________________` `___________________________1151_____________________________________1192____________________1216_1221___________________` `1brw(B) : IDKLESVPGFHVEISKDEFIRLVNENGIAIIGQTGDLTPADKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKKLDEARRLARVMVDIGKRVGRRTMAVISDMS` `:` `1brw(A) : IDKLESVPGFHVEISKDEFIRLVNENGIAIIGQTGDLTPADKKLYALRDVTATVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKKLDEARRLARVMVDIGKRVGRRTMAVISDMS` `____________________________151______________________________________192_____________________216__221___________________` `________________________________________________________________________________________________________________________` `1brw(B) : QPLGYAVGNALEVKEAIETLKGNGPHDLTELCLTLGSHMVYLAEKAPSLDEARRLLEEAIRSGAAIAAFKTFLAAQGGDASVVDDLDKLPKAAYTSTVTAAADGYVAEMAADDIGTAAMW` `:` `1brw(A) : QPLGYAVGNALEVKEAIETLKGNGPHDLTELCLTLGSHMVYLAEKAPSLDEARRLLEEAIRSGAAIAAFKTFLAAQGGDASVVDDLDKLPKAAYTSTVTAAADGYVAEMAADDIGTAAMW` `________________________________________________________________________________________________________________________` `_________________________________________________________________________` `1brw(B) : LGAGRAKKEDVIDLAVGIVLHKKIGDRVQKGEALATIHSNRPDVLDVKEKIEAAIRLSPQPVARPPLIYETIV` `:` `1brw(A) : LGAGRAKKEDVIDLAVGIVLHKKIGDRVQKGEALATIHSNRPDVLDVKEKIEAAIRLSPQPVARPPLIYETIV` `_________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	20.1
Translation (A)	0.8
Closure (%)	98.0
Bending Residues ( green )	1066 - 1070 1151 - 1158 1192 - 1193 1216 - 1218 1221 - 1222
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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