Mitogen-Activated Protein Kinase 8

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Mitogen-Activated Protein Kinase 8
  Conformer 1
(PDB) 		4ux9 (A)
  Conformer 2
(PDB) 		1ukh (A)
  Window Length 7
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 214 2.0   80 - 87   110 - 337
2 98 0.55   12 - 79   88 - 109   350 - 359

Sequence


           ______________________________________________________________________79______87___________________109__________________ 
 4ux9(A) : NNFYSVEIGDSTFTVLKRYQNLKPIGSGA-gIVCAAYDAILERNVAIKKLS-pFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHER 
         :                                                                                                                          
 1ukh(A) : *NFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHER 
           ______________________________________________________________________79______87___________________109__________________ 

           ________________________________________________________________________________________________________________________ 
 4ux9(A) : MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTpYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKL 
         :                                                                                                                          
 1ukh(A) : MSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL------------yYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKL 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________________________________334_______________________                
 4ux9(A) : QPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPrEHTIEEWKELIYKEVMDL                
         :                                                                                                                          
 1ukh(A) : QPTVRTYVENRPKYAGYSFEKLFPDVLFP-----nKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKi------EEWKELIYKEVMDL                
           _______________________________________________________________________________334_______________________                

Morph

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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		14.2
Translation
(A) 		-0.6
Closure
(%) 		68.0
Bending Residues
( green ) 		  79 - 80
  87 - 88
  109 - 110
  334 - 352
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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