Mitogen-Activated Protein Kinase 8

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Mitogen-Activated Protein Kinase 8
  Conformer 1
(PDB) 		4ux9 (D)
  Conformer 2
(PDB) 		1ukh (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 210 1.27   77 - 77   79 - 86   111 - 332   335 - 335
2 100 2.37   11 - 76   78 - 78   87 - 110   333 - 334   336 - 360

Sequence


           __________________________________________________________________76________86_____________________110__________________ 
 4ux9(D) : NFYSVEIGDSTFTVLKRYQNLKPI------iVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERM 
         :                                                                                                                          
 1ukh(A) : NFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERM 
           __________________________________________________________________76________86_____________________110__________________ 

           ________________________________________________________________________________________________________________________ 
 4ux9(D) : SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEF 
         :                                                                                                                          
 1ukh(A) : SYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGL-----------------yYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEF 
           ________________________________________________________________________________________________________________________ 

           ______________________________________________________________________________332_____________________________           
 4ux9(D) : MKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADnKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDdEREHTIEEWKELIYKEVMDLE           
         :                                                                                                                          
 1ukh(A) : MKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFP--nKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKi---------EEWKELIYKEVMDL*           
           ______________________________________________________________________________332_____________________________           

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		19.6
Translation
(A) 		-0.5
Closure
(%) 		100.0
Bending Residues
( green ) 		  76 - 79
  86 - 87
  110 - 111
  332 - 337
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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