Serine Hydroxymethyltransferase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Serine Hydroxymethyltransferase
  Conformer 1
(PDB) 		6uxh (A)
  Conformer 2
(PDB) 		6uxj (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 287 0.5   2 - 31   41 - 124   133 - 158   161 - 188   193 - 194   202 - 312   315 - 315   393 - 394   459 - 468
2 169 0.69   32 - 40   125 - 132   159 - 160   189 - 192   195 - 201   313 - 314   316 - 392   395 - 458

Sequence


           _______________________________31_______40______________________________________________________________________________ 
 6uxh(A) : SHMDPVSVWGNTPLATVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYGGNEYIDQIENLCRSRALQAFHLDAQSWGVNVQPYSGSPANFAAYTAVL 
         :                                                                                                                          
 6uxj(A) : *HMDPVSVWGNTPLATVDPEIHDLIEKEKRRQCRGIELIASENFTSFAVIEALGSALTNKYSEGMPGNRYYGGNEYIDQIENLCRSRALQAFHLDAQSWGVNVQPYSGSPANFAAYTAVL 
           _______________________________31_______40______________________________________________________________________________ 

           ___124_____132_______________________158___________________________188_192______201_____________________________________ 
 6uxh(A) : NPHDRIMGLDLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSTTGYIDYDRLEEKALDFRPKLIICGGSAYPRDWDYKRFREVADKCGALLLCDMAHTSGLVAAQEVNSPFEYCDIV 
         :                                                                                                                          
 6uxj(A) : NPHDRIMGLDLPSGGHLTHGYYTSGGKKISATSIYFESLPYKVNSTTGYIDYDRLEEKALDFRPKLIICGGSAYPRDWDYKRFREVADKCGALLLCDMAHTSGLVAAQEVNSPFEYCDIV 
           ___124_____132_______________________158___________________________188_192______201_____________________________________ 

           _______________________________________________________________________312______________________________________________ 
 6uxh(A) : TTTTH-sLRGPRAGMIFYRKGPKP------eNAVYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAASPGFKAYAKQVKANAVALGKYLMGKGYSLVTGGTENHLVLWDLRPLGLTGN 
         :                                                                                                                          
 6uxj(A) : TTTTHKSLRGPRAGMIFYRKGPKPPKKGQPENAVYDFEDKINFAVFPSLQGGPHNHQIGALAVALKQAASPGFKAYAKQVKANAVALGKYLMGKGYSLVTGGTENHLVLWDLRPLGLTGN 
           _______________________________________________________________________312______________________________________________ 

           _______________________________392_______________________________________________________________458____________         
 6uxh(A) : KVEKLCDLCNITVNKNAVFGD----aPGGVRIGAPAMTSRGLVEKDFEQIGEFLHRAVTLTLEIQKEHGKLLKDFNKGLVNNKAIEDLKADVEKFSALFDMPGFLVSEMKYK         
         :                                                                                                                          
 6uxj(A) : KVEKLCDLCNITVNKNAVFGDSSALAPGGVRIGAPAMTSRGLVEKDFEQIGEFLHRAVTLTLEIQKEHGKLLKDFNKGLVNNKAIEDLKADVEKFSALFDMPGFLVSEMKYK         
           _______________________________392_______________________________________________________________458____________         

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		5.2
Translation
(A) 		0.0
Closure
(%) 		82.9
Bending Residues
( green ) 		  31 - 32
  40 - 41
  124 - 125
  132 - 134
  158 - 161
  188 - 189
  192 - 195
  201 - 202
  312 - 316
  392 - 395
  458 - 459
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

PyMOL Script

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