Insulin Receptor Tyrosine Kinase Domain

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Insulin Receptor Tyrosine Kinase Domain
  Conformer 1
(PDB) 		1irk (A)
  Conformer 2
(PDB) 		1luf (A)
  Window Length 11
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 244 1.67   987 - 1029   1051 - 1263
2 21 1.26   1030 - 1050

Sequence


           _____________________________________________1029_________________1050__________________________________________________ 
 1irk(A) : SSVFVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPG 
         :                                                                                                                          
 1luf(A) : *LNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSP------- 
           ______________________________________________607__________________628__________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 1irk(A) : RPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLK 
         :                                                                                                                          
 1luf(A) : -pPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYY----KdAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIY 
           ________________________________________________________________________________________________________________________ 

           _______________________________________________________________                                                          
 1irk(A) : FVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHSEENK                                                          
         :                                                                                                                          
 1luf(A) : YVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRMCE***************                                                          
           _______________________________________________________________                                                          

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		22.3
Translation
(A) 		0.7
Closure
(%) 		39.4
Bending Residues
( green ) 		  1029 - 1030
  1050 - 1051
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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