DynDom - Protein Domain Motions

M-Calpain Large Subunit

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	M-Calpain Large Subunit
Conformer 1 (PDB)	1kfx (L)
Conformer 2 (PDB)	2ary (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	206	2.97	25 - 211 217 - 217 287 - 296 335 - 342
2	68	1.8	212 - 216 218 - 286 325 - 334

Sequence

`________________________________________________________________________________________________________________________` `1kfx(L) : AGIAAKLAKDREAAEGLGSHERAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGMRWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEIL` `:` `2ary(A) : *******************NAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLL` `________________________________________________________________________________________________________________________` `_______________________________________________________________________________________211__216_________________________` `1kfx(L) : ARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCS` `:` `2ary(A) : HRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCS` `_______________________________________________________________________________________221__226_________________________` `__________________________________________286___292_____________________________________________________________________` `1kfx(L) : ID----------------kGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRw----------------------------MSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKM` `:` `2ary(A) : IDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLT*************` `__________________________________________296___302_____________________________________________________________________` `________________________________________________________________________________________________________________________` `1kfx(L) : DGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEcTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEEtNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNK` `:` `2ary(A) : ********************************************************************************************************************` `________________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `1kfx(L) : DGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGVRRLFAQLAGEDAEISAFELQTILRRVLAKRkSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDV` `:` `2ary(A) : ********************************************************************************************************************` `________________________________________________________________________________________________________________________` `____________________________________________________________________________________` `1kfx(L) : DRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL` `:` `2ary(A) : **********************************************************************************` `____________________________________________________________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	25.1
Translation (A)	-0.9
Closure (%)	60.2
Bending Residues ( green )	211 - 212 216 - 218 286 - 287 292 - 335
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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