DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor 2
Conformer 1 (PDB)	5kzq (A)
Conformer 2 (PDB)	5kzn (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	170	0.62	190 - 318 453 - 494
2	274	0.82	26 - 189 319 - 452
3	49	1.57	498 - 546

Sequence

`________________________________________________________________________________________________________________________` `5kzq(A) : KVLTLEGDLVLGGLFPVHQK--pAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLpTAITGVIGGSYSDVSIQVANLLRLFQIPQIS` `:` `5kzn(A) : KKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLpTAITGVIGGSYSDVSIQVANLLRLFQIPQIS` `________________________________________________________________________________________________________________________` `______________________189_______________________________________________________________________________________________` `5kzq(A) : YASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQR` `:` `5kzn(A) : YASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQR` `______________________189_______________________________________________________________________________________________` `_______________________________318______________________________________________________________________________________` `5kzq(A) : LNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTT` `:` `5kzn(A) : LNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTT` `_______________________________318______________________________________________________________________________________` `_____________________________________________452______________________________________494_______________________________` `5kzq(A) : RLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGgRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPC` `:` `5kzn(A) : RLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGgRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPC` `_____________________________________________452______________________________________494_______________________________` `__________________________` `5kzq(A) : QPYEYRLDEFTCADCGLGYWPNASLT` `:` `5kzn(A) : QPYEYRLDEFTCADCGLGYWPNA**` `__________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
For more advanced options, right click on the model.

Show console

play backwards

pause

play forwards

Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	21.0
Translation (A)	0.9
Closure (%)	60.5
Bending Residues ( green )	189 - 192 318 - 319 452 - 453
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	19.7
Translation (A)	-1.6
Closure (%)	79.2
Bending Residues ( green )	494 - 499
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Mixed

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification:

No Contacts

PyMOL Script

Download and extract PyMOL PML script file