Pyruvate Kinase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Pyruvate Kinase
  Conformer 1
(PDB) 		5wrp (C)
  Conformer 2
(PDB) 		5ws8 (C)
  Window Length 13
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 311 6.02   30 - 35   52 - 449
2 23 6.04   14 - 29   36 - 42

Sequence


           _______________________________________________________________________________________________________________________2 
 5wrp(C) : *********************************************************************************************TRRGKIVCTLGPATQRDDLVRALVEAG 
         :                                                                                                                          
 5ws8(C) : TRRGKIVCTLGPATQRDDLVRALVEAGMDVARMNFSHGDYDDHKVAYERVRVASDATGRAVGVLADLQGPKIRLGRFASGATHWAEGETVRITVGACEGSHDRVSTTYKRLAQDAVAGDR 
           ______________________________________________________________________________________________________________________12 

           9___________42__________________________________________________________________________________________________________ 
 5wrp(C) : MDVARMNFSHGDYDDHKVAYERVR---VASDATGR---A----VGVLADLQGPtAPALSEKDIEDLTFALNLGVDMVALSFVRSPADVELVHEVMDRIGRRVPVIAKLEKPEAIDNLEAI 
         :                                                                                                                          
 5ws8(C) : VLVDDGKVALVVDAVEGDDVVCTVVEGGPVSDNKGISLPGMNVTAPALSEKDIEDLTFALNLGVDMVALSFVRSPADVELVHEVMDRIGRRVPVIAKLEKPEAIDNLEAIVLAFDAVMVA 
           2__________135__________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 5wrp(C) : VLAFDAVMVARGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIICAVEENSTAAPPLTHIPRTKR 
         :                                                                                                                          
 5ws8(C) : RGDLGVELPLEEVPLVQKRAIQMARENAKPVIVATQMLDSMIENSRPTRAEASDVANAVLDGADALMLSGETSVGKYPLAAVRTMSRIICAVEENSTAAPPLTHIPRTKRGVISYAARDI 
           ________________________________________________________________________________________________________________________ 

           ________________________________________________________________________________________________________________________ 
 5wrp(C) : GVISYAARDIGERLDAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVPKMQSTDGMIRQVDKSLLELARYKRGDLVVIVAGAPPGTVGSTNLIHVHRIGEDD 
         :                                                                                                                          
 5ws8(C) : GERLDAKALVAFTQSGDTVRRLARLHTPLPLLAFTAWPEVRSQLAMTWGTETFIVPKMQSTDGMIRQVDKSLLELARYKRGDLVVIVAGsTNLIHVHRI-------GEDDV********* 
           ________________________________________________________________________________________________________________________ 

           _                                                                                                                        
 5wrp(C) : V                                                                                                                        
         :                                                                                                                          
 5ws8(C) : *                                                                                                                        
           _                                                                                                                        

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		133.9
Translation
(A) 		-24.1
Closure
(%) 		40.7
Bending Residues
( green ) 		  29 - 37
  42 - 63
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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