DynDom - Protein Domain Motions

Regulator Of Nonsense Transcripts 1

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Regulator Of Nonsense Transcripts 1
Conformer 1 (PDB)	2gk7 (A)
Conformer 2 (PDB)	2gjk (A)
Window Length	9
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	333	1.03	299 - 317 319 - 326 331 - 344 352 - 355 389 - 391 397 - 412 417 - 664 666 - 697
2	255	0.85	318 - 318 327 - 330 345 - 351 356 - 388 392 - 396 413 - 416 665 - 665 698 - 904

Sequence

`________________________317______326_______________344____351__________________________________388_____396_____________4` `2gk7(A) : ****RYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLG--kKRIAYFTLPKTDSDMRLMQGDEICLRY-------wKGIGHVIKVPDNYGDEIAIELRSSVG-----tHNFQ` `:` `2gjk(A) : PLGSRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRIAYFTLPKTDSDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPVEVTHNFQ` `________________________317______326_______________344____351__________________________________388_____396_____________4` `12_416__________________________________________________________________________________________________________________` `2gk7(A) : VDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQL` `:` `2gjk(A) : VDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHEVEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQL` `12_416__________________________________________________________________________________________________________________` `________________________________________________________________________________________________________________________` `2gk7(A) : TEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDEsSADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVVLGA` `:` `2gjk(A) : TEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDEsSADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVVLGA` `________________________________________________________________________________________________________________________` `_______664_____________________________696______________________________________________________________________________` `2gk7(A) : KQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAANVE` `:` `2gjk(A) : KQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAANVE` `_______664_____________________________696______________________________________________________________________________` `________________________________________________________________________________________________________________________` `2gk7(A) : KITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKE` `:` `2gjk(A) : KITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKE` `________________________________________________________________________________________________________________________` `______________` `2gk7(A) : QKVLVEGPLNNLRE` `:` `2gjk(A) : QKVLVEGPLNNLRE` `______________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	8.2
Translation (A)	0.2
Closure (%)	98.7
Bending Residues ( green )	317 - 321 326 - 332 344 - 345 351 - 356 388 - 389 391 - 392 396 - 397 412 - 413 416 - 417 664 - 666 696 - 701
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Shear

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