S-Adenosyl-L-Homocysteine Hydrolase

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name S-Adenosyl-L-Homocysteine Hydrolase
  Conformer 1
(PDB) 		1k0u (G)
  Conformer 2
(PDB) 		1b3r (C)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 212 0.61   187 - 355   385 - 390   393 - 429
2 210 0.56   8 - 186   356 - 384   391 - 392

Sequence


           ________________________________________________________________________________________________________________________ 
 1k0u(G) : DKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKD 
         :                                                                                                                          
 1b3r(C) : **LPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVRWSSCNIFSTQDHAAAAIAKAGIPVFAWKGETDEEYLWCIEQTLHFKD 
           ________________________________________________________________________________________________________________________ 

           _____________________________________________________________185________________________________________________________ 
 1k0u(G) : GPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIIT 
         :                                                                                                                          
 1b3r(C) : GPLNMILDDGGDLTNLIHTKHPQLLSGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIIT 
           _____________________________________________________________185________________________________________________________ 

           ______________________________________________________________________________________________________________354_______ 
 1k0u(G) : EIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSF 
         :                                                                                                                          
 1b3r(C) : EIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYLLKNGHRIILLAEGRLVNLGCAMGHPSFVMSNSF 
           ______________________________________________________________________________________________________________354_______ 

           ___________________383_387____________________________________________                                                   
 1k0u(G) : TNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY                                                   
         :                                                                                                                          
 1b3r(C) : TNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMPINGPFKPDHYRY                                                   
           ___________________383_387____________________________________________                                                   

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		15.2
Translation
(A) 		-0.1
Closure
(%) 		98.9
Bending Residues
( green ) 		  185 - 191
  354 - 357
  383 - 385
  387 - 393
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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