DynDom - Protein Domain Motions

Uncharacterized RNA Methyltransferase Pyrab10780

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Uncharacterized RNA Methyltransferase Pyrab10780
Conformer 1 (PDB)	2jjq (A)
Conformer 2 (PDB)	2vs1 (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	227	0.29	24 - 27 55 - 110 135 - 144 178 - 184 234 - 244 248 - 248 254 - 403
2	48	0.45	3 - 23 28 - 54
3	112	0.44	111 - 134 145 - 177 185 - 233 245 - 247 249 - 253

Sequence

`________________________23__27_________________________54_____________________________________________110_______________` `2jjq(A) : ***MRGVIRKLNDDGFGVLKGILVPFSAPGDEIIVERVERVKKRRVASQWKLVRSSPLRV---gCTLQHLNYDYQLEFKRKKLKRILGFEVEVVPSPKIFGHRNRIDLAITKDGIGFREk` `:` `2vs1(A) : GSHMRGVIRKLNDDGFGVLKGILVPFSAPGDEIIVERVERVKKRRVASQWKLVRSSPLRVkCGGCTLQHLNYDYQLEFKRKKLKRILGFEVEVVPSPKIFGHRNRIDLAITKDGIGFREk` `________________________23__27_________________________54_____________________________________________110_______________` `____134_______144______________________________177____184______________________________________________233________244___` `2jjq(A) : WWKIVDIDECPVFGKTSREAIERLKEFIEEEKISVWNIKKDEGFLRYMVLREGKFTEEVMVNFVTKEGNLPDPTNYFDFDSIYWSVNRSKSDVSYGDIERFWGKEFIRERLDDVDYLIHP` `:` `2vs1(A) : WWKIVDIDE-pVFGKTSREAIERLKEFIEEEKISVWNIKKDEGFLRYMVLREGKFTEEVMVNFVTKEGNLPDPTNYFDFDSIYWSVNRSKSDVSYGDIERFWGKEFIRERLDDVDYLIHP` `____134_______144______________________________177____184______________________________________________233________244___` `___253__________________________________________________________________________________________________________________` `2jjq(A) : NSFFQTNSYQAVNLVRKVSELVEGEKILDMYSGVGTFGIYLAKRGFNVKGFDSNEFAIEMARRNVEINNVDAEFEVASDREVSVKGFDTVIVDPPRAGLHPRLVKRLNREKPGVIVYVSC` `:` `2vs1(A) : NSFFQTNSYQAVNLVRKVSELVEGEKILDMYSGVGTFGIYLAKRGFNVKGFDSNEFAIEMARRNVEINNVDAEFEVASDREVSVKGFDTVIVDPPRAGLHPRLVKRLNREKPGVIVYVSC` `___253__________________________________________________________________________________________________________________` `______________________________________` `2jjq(A) : NPETFARDVKMLDYRIDEIVALDMFPHTPHVELVAKLV` `:` `2vs1(A) : NPETFARDVKMLDYRIDEIVALDMFPHTPHVELVAKLV` `______________________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	5.3
Translation (A)	-0.1
Closure (%)	53.1
Bending Residues ( green )	23 - 24 27 - 28 54 - 55
Bending Region Analysis

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( yellow )	3
Rotation Angle (deg)	4.1
Translation (A)	0.1
Closure (%)	87.0
Bending Residues ( green )	110 - 111 134 - 135 144 - 145 177 - 180 184 - 185 233 - 234 244 - 245 247 - 249 253 - 254
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

Conformer 1 Contact:
Residue 1 ———› Residue 3

Conformer 2 Contact:
Residue 3 ———› Residue 1

Movement classification: Shear

PyMOL Script

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