Metabotropic Glutamate Receptor 3

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Metabotropic Glutamate Receptor 3
  Conformer 1
(PDB) 		3sm9 (A)
  Conformer 2
(PDB) 		1ewk (A)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 262 2.59   7 - 169   301 - 436
2 163 1.37   170 - 300   437 - 470

Sequence


           ________________________________________________________________________________________________________________________ 
 3sm9(A) : RREIKIEGDLVLGGLF-----PINEKGTtEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASlLIAGVIGGSYSSVSIQVANLLRLFQIPQ 
         :                                                                                                                          
 1ewk(A) : RSVARMDGDVIIGALFSVHHQPPAEKVPERKCGEIREQYGIQRVEAMFHTLDKINADPVLLPNITLGSEIRDSCWHSSVALEQSIEFIRkP--IAGVIGPGSSSVAIQVQNLLQLFDIPQ 
           ________________________________________________________________________________________________________________________ 

           _______________________169______________________________________________________________________________________________ 
 3sm9(A) : ISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNISIATAEKV--GRiRKSYDSVIRELLQK-PNARVVVLFMRSDDSRELIAA 
         :                                                                                                                          
 1ewk(A) : IAYSATSIDLSDKTLYKYFLRVVPSDTLQARAMLDIVKRYNWTYVSAVHTEGNYGESGMDAFKELAAQEGLCIAHSDKIYSNAGEKSFDRLLRKLRERLPKARVVVCFCEGMTVRGLLSA 
           _______________________208______________________________________________________________________________________________ 

           _____________________________________300________________________________________________________________________________ 
 3sm9(A) : ASRANA--SFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQnH-------RRVCDKHLAIDSSNYEQESKIMFVVNAVYAMA 
         :                                                                                                                          
 1ewk(A) : MRRLGVVGEFSLIGSDGWADRDEVIEGYEVEANGGITIKLQSPEVRSFDDYFLKLRLDTNTRNPWFPEFWQHRFQCRLPGHLLENPNFKKVCTGNESLEE-NYVQDSKMGFVINAIYAMA 
           _____________________________________342________________________________________________________________________________ 

           ____________________________________________________436_________________________________________                         
 3sm9(A) : HALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNdSIVKFDTFGDGMGRYNVFNFQNV-GGKYSYLKVGHWAE-TLSLDVNSIHWS                         
         :                                                                                                                          
 1ewk(A) : HGLQNMHHALCPGHVGLCDAMKPIDGRKLL-DFLIKSSFVGVSGEE-VWFDEKGDAPGRYDIMNLQYTEANRYDYVHVGTWHEGVLNIDDYKI***                         
           ____________________________________________________474_________________________________________                         

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		24.0
Translation
(A) 		-0.3
Closure
(%) 		99.9
Bending Residues
( green ) 		  169 - 170
  300 - 301
  436 - 437
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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