DynDom - Protein Domain Motions

Metabotropic Glutamate Receptor 2

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

Property	Value
Name	Metabotropic Glutamate Receptor 2
Conformer 1 (PDB)	4xaq (A)
Conformer 2 (PDB)	5kzn (A)
Window Length	5
Minimum ratio	1.0
Minimum domain size	20

Domains

Domain	Size	Backbone RMSD (A)	Residues
1	274	0.84	25 - 189 321 - 452
2	163	0.69	190 - 320 453 - 485

Sequence

`________________________________________________________________________________________________________________________` `4xaq(A) : AKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASL-tAITGVIGGSYSDVSIQVANLLRLFQIPQI` `:` `5kzn(A) : KKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLpTAITGVIGGSYSDVSIQVANLLRLFQIPQI` `________________________________________________________________________________________________________________________` `_____________________187________________________________________________________________________________________________` `4xaq(A) : SYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNISVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQ` `:` `5kzn(A) : SYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQ` `_____________________187________________________________________________________________________________________________` `_________________________________319____________________________________________________________________________________` `4xaq(A) : RLNASFTWVASDGWGALEEVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNT` `:` `5kzn(A) : RLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNT` `_________________________________319____________________________________________________________________________________` `__________________________________________448___________________________________________________________________________` `4xaq(A) : TRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPW*********************************` `:` `5kzn(A) : TRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAG-gRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCI` `__________________________________________448___________________________________________________________________________` `_________________________` `4xaq(A) : ***********************` `:` `5kzn(A) : PCQPYEYRLDEFTCADCGLGYWPNA` `_________________________`

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property	Value
Fixed Domain ( blue )	1
Moving Domain ( red )	2
Rotation Angle (deg)	44.6
Translation (A)	1.9
Closure (%)	97.8
Bending Residues ( green )	187 - 192 319 - 327 448 - 453
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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