Proto-Oncogene Cbl

(All numbering and residues are taken from first PDB file)

Run Details Domains Sequence Morph Domain Pairs Contact Graph

DynDom run details

  Property   Value
  Name Proto-Oncogene Cbl
  Conformer 1
(PDB) 		2cbl (A)
  Conformer 2
(PDB) 		1b47 (B)
  Window Length 5
  Minimum ratio 1.0
  Minimum domain size 20

Domains

Domain Size Backbone RMSD
(A)		 Residues
1 221 0.8   51 - 260   270 - 273   295 - 301
2 77 0.51   261 - 269   274 - 294   302 - 348

Sequence


           ________________________________________________________________________________________________________________________ 
 2cbl(A) : PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK 
         :                                                                                                                          
 1b47(B) : PPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELK 
           ________________________________________________________________________________________________________________________ 

           __________________________________________________________________________________________259_______269_________________ 
 2cbl(A) : GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH 
         :                                                                                                                          
 1b47(B) : GIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIH 
           __________________________________________________________________________________________259_______269_________________ 

           _____294____301__________________________________________________                                                        
 2cbl(A) : KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTG                                                        
         :                                                                                                                          
 1b47(B) : KPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLT*                                                        
           _____294____301__________________________________________________                                                        

Morph

This morph was created using the MorphIt_Pro protein morphing technique.
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Domain Pairs

Property Value
Fixed Domain
( blue ) 		1
Moving Domain
( red ) 		2
Rotation Angle
(deg) 		15.4
Translation
(A) 		0.3
Closure
(%) 		61.3
Bending Residues
( green ) 		  259 - 262
  269 - 274
  294 - 298
  301 - 302
Bending Region Analysis

Dynamic Contact Graph

Conformer 1 Contact:
Residue 1 ———› Residue 2

Conformer 2 Contact:
Residue 2 ———› Residue 1

Movement classification: Hinge

PyMOL Script

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